Freebily publications

A cluster randomized controlled trial for assessing POC-CCA test based praziquantel treatment for schistosomiasis control in pregnant women and their young children: study protocol of the freeBILy clinical trial in Madagascar
Daniela Fusco, Raphäel Rakotozandrindrainy, Rivo Andry Rakotoarivelo, Mala Rakoto Andrianarivelo,Njary Rakotozandrindrainy, Tahinamandranto Rasamoelina, Dewi Ismajani Puradiredja, Philipp Klein, Karl Stahlberg, Marie Dechenaud, Eva Lorenz1, Anna Jaeger, Andrea Kreidenweiss, Pytsje T. Hoekstra, Akim Ayola Adegnika, Elisa Sicuri, Paul L. A. M. Corstjens, Govert J. van Dam, Jürgen May, Norbert Georg Schwarz and on behalf of the freeBILy consortium (2021)
Trials 22:822 https://doi.org/10.1186/s13063-021-05769-6

Occurrence of Schistosomiasis in Madagascar Assessing the prevalence of schistosomiasis in pregnant women in Tsiroanomandidy and Ampefy in the Madagascan Highlands using a rapid diagnostic test.
Dissertation by Karl Stahlberg
January 2021

Prospective, observational study to assess the performance of CAA measurement as a diagnostic tool for the detection of Schistosoma haematobium infections in pregnant women and their child in Lambaréné, Gabon: study protocol of the freeBILy clinical trial in Gabon
Daniela Fusco, Raphäel Rakotozandrindrainy, Rivo Andry Rakotoarivelo, Mala Rakoto Andrianarivelo, Njary Rakotozandrindrainy, Tahinamandranto Rasamoelina, Dewi Ismajani Puradiredja, Philipp Klein, Karl Stahlberg, Marie Dechenaud, Eva Lorenz, Anna Jaeger, Andrea Kreidenweiss, Pytsje T. Hoekstra, Akim Ayola Adegnika, Elisa Sicuri, Paul L. A. M. Corstjens, Govert J. van Dam, Jürgen May, Norbert Georg Schwarz and on behalf of the freeBILy consortium
BMC Infectious Diseases, Published: 29 September 2020

Fast and reliable easy-to-use diagnostics for eliminating bilharzia in young children and mothers: An introduction to the freeBILy project
Pytsje T. Hoekstra, Norbert G. Schwarz, Ayola A. Adegnika, Mala Rakoto Andrianarivelo, Paul L.A.M. Corstjens, Rivo A. Rakotoarivelo, Raphaël Rakotozandrindrainy, Elisa Sicuri, Andrea Kreidenweiss, Govert J. van Dam, on behalf of the freeBILy consortium (2020).
Acta Tropica, 211, 105631. doi: 10.1016/j.actatropica.2020.105631

Background

Schistosomiasis in young children:

Schistosomiasis in African infants and preschool children: let them now be treated!
Stothard, J. R., Sousa-Figueiredo, J. C., Betson, M., Bustinduy, A., & Reinhard-Rupp, J. (2013).
Trends Parasitol, 29(4), 197-205. doi: 10.1016/j.pt.2013.02.001

Schistosomiasis in pre-school-age children and their mothers in Chikhwawa district, Malawi with notes on characterization of schistosomes and snails.
Poole, H., Terlouw, D. J., Naunje, A., Mzembe, K., Stanton, M., Betson, M., Lalloo, D.G., Stothard, J. R. (2014).
Parasit Vectors, 7, 153. doi: 10.1186/1756-3305-7-153

One hundred years of neglect in paediatric schistosomiasis.
Bustinduy, A. L., Wright, S., Joekes, E. C., Kabatereine, N. B., Reinhard-Rupp, J., King, C. H., & Stothard, J. R. (2017).
Parasitology, 144(12), 1613-1623. doi: 10.1017/s0031182017000014

Schistosomiasis and pregnancy:

Tackling neglect: treating schistosomiasis in pregnancy.
Luty, A. J., & Elliott, A. M. (2016).
Lancet Infect Dis, 16(2), 137-139. doi: 10.1016/s1473-3099(15)00379-5

Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial.
Olveda, R. M., Acosta, L. P., Tallo, V., Baltazar, P. I., Lesiguez, J. L., Estanislao, G. G., Ayaso, E.B., Monterde, D.B., Ida, A., Watson, N., McDonald, E.A., Wu, H.W., Kurtis, J.D., Friedman, J. F. (2016).
Lancet Infect Dis, 16(2), 199-208. doi: 10.1016/s1473-3099(15)00345-x

Paediatric and maternal schistosomiasis: shifting the paradigms.
Bustinduy, A. L., Stothard, J. R., & Friedman, J. F. (2017).
Br Med Bull, 123(1), 115-125. doi: 10.1093/bmb/ldx028

Praziquantel for the treatment of schistosomiasis during human pregnancy.
Friedman, J. F., Olveda, R. M., Mirochnick, M. H., Bustinduy, A. L., & Elliott, A. M. (2018).
Bull World Health Organ, 96(1), 59-65. doi: 10.2471/blt.17.198879

Infection by Schistosoma mansoni during pregnancy: Effects on offspring immunity.
da Paz, V. R. F., Sequeira, D., & Pyrrho, A. (2017).
Life Sci, 185, 46-52. doi: 10.1016/j.lfs.2017.07.021

Schistosomiasis in the first 1000 days.
Freer, J. B., Bourke, C. D., Durhuus, G. H., Kjetland, E. F., & Prendergast, A. J. (2018).
Lancet Infect Dis, 18(6), e193-e203. doi: 10.1016/s1473-3099(17)30490-5

Schistosomiasis diagnostics:

A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni.
Colley, D. G., Binder, S., Campbell, C., King, C. H., Tchuem Tchuente, L. A., N’Goran, E. K., Erko, B., Karanja, D.M., Kabatereine, N.B., van Lieshout, L., Rathbun, S. (2013).
Am J Trop Med Hyg, 88(3), 426-432. doi: 10.4269/ajtmh.12-0639

Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels.
Corstjens, P. L., De Dood, C. J., Kornelis, D., Fat, E. M., Wilson, R. A., Kariuki, T. M., Nyakundi, R.K., Loverde, P.T., Abrams, W.R., Tanke, H.J., Van Lieshout, L., Deelder, A.M., Van Dam, G. J. (2014).
Parasitology, 141(14), 1841-1855. doi: 10.1017/S0031182014000626

New diagnostic tools in schistosomiasis.
Utzinger, J., Becker, S. L., van Lieshout, L., van Dam, G. J., & Knopp, S. (2015).
Clin Microbiol Infect, 21(6), 529-542. doi: 10.1016/j.cmi.2015.03.014

Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes. 
Corstjens, P. L., Nyakundi, R. K., de Dood, C. J., Kariuki, T. M., Ochola, E. A., Karanja, D. M., Mwinzi, P.N., van Dam, G. J. (2015).
Parasit Vectors, 8, 241. doi: 10.1186/s13071-015-0857-7

Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi. 
Clements, M. N., Corstjens, P., Binder, S., Campbell, C. H., Jr., de Dood, C. J., Fenwick, A., Harrison, W., Kayugi, D., King, C.H., Kornelis, D., Ndayishimiye, O., Ortu, G., Lamine, M.S., Zivieri, A., Colley, D.G., van Dam, G. J. (2018).
Parasit Vectors, 11(1), 111. doi: 10.1186/s13071-018-2700-4

Diagnosis of schistosomiasis mansoni: an evaluation of existing methods and research towards single worm pair detection. 
Ogongo, P., Kariuki, T. M., & Wilson, R. A. (2018).
Parasitology, 1-12. doi: 10.1017/s0031182018000240

Schistosomiasis in Gabon:

Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon.
Manego, R. Z., Mombo-Ngoma, G., Witte, M., Held, J., Gmeiner, M., Gebru, T., Tazemda, B., Mischlinger, J., Groger, M., Lell, B., Adegnika, A.A., Agnandji, S.T., Kremsner, P.G., Mordmüller, B., Ramharter, M., Matsiegui, P. B. (2017).
BMC Public Health, 17(1), 130. doi: 10.1186/s12889-017-4045-x

Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon. 
Mombo-Ngoma, G., Honkpehedji, J., Basra, A., Mackanga, J. R., Zoleko, R. M., Zinsou, J., Agobe, J.C., Lell, B., Matsiegui, P.B., Gonzales, R., Agnandji, S.T., Yazdanbakhsh, M., Menendez, C., Kremsner, P.G., Adegnika, A.A., Ramharter, M. (2017).
Int J Parasitol, 47(1), 69-74. doi: 10.1016/j.ijpara.2016.11.001

Schistosomiasis in Madagascar:

Gynecological manifestations, histopathological findings, and schistosoma-specific polymerase chain reaction results among women with Schistosoma haematobium infection: a cross-sectional study in Madagascar.
Randrianasolo, B. S., Jourdan, P. M., Ravoniarimbinina, P., Ramarokoto, C. E., Rakotomanana, F., Ravaoalimalala, V. E., Gundersen, S.G., Feldmeier, H., Vennervald, B.J., van Lieshout, L., Roald, B., Leutscher, P., Kjetland, E. F. (2015).
J Infect Dis, 212(2), 275-284. doi: 10.1093/infdis/jiv035

Baseline prevalence and intensity of schistosomiasis at sentinel sites in Madagascar: Informing a national control strategy. 
Rasoamanamihaja, C. F., Rahetilahy, A. M., Ranjatoarivony, B., Dhanani, N., Andriamaro, L., Andrianarisoa, S. H., & Jourdan, P. M. (2016).
Parasit Vectors, 9, 50. doi: 10.1186/s13071-016-1337-4

Schistosoma mansoni in schoolchildren in a Madagascan highland school assessed by PCR and sedimentation microscopy and Bayesian estimation of sensitivities and specificities.
Schwarz, N. G., Rakotozandrindrainy, R., Heriniaina, J. N., Randriamampionona, N., Hahn, A., Hogan, B., Frickmann, H., Dekker, D., Poppert, S., Razafindrabe, T., Rakotondrainiarivelo, J.P., May, J., Hagen, R. M. (2014).
Acta Trop, 134, 89-94. doi: 10.1016/j.actatropica.2014.03.003

High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar.
Spencer, S. A., Penney, J., Russell, H. J., Howe, A. P., Linder, C., Rakotomampianina, A. L. D., Rakotomampianina, Nandimbiniaina, A.M., Squire, S.B., Stothard, J.R., Bustinduy, A.L. and Rahetilahy, A. M. (2017).
Parasit Vectors, 10(1), 307. doi: 10.1186/s13071-017-2249-7